ABSTRACT
Objective Objective To evaluate the efficacy of Heqi San combined with metformin in the treatment of obese polycystic ovary syndrome (PCOS). Methods A total of 60 patients with obese polycystic ovary syndrome who met the inclusion criteria were randomly divided into 2 groups, 30 patients in each group. The control group was treated with metformin, and the treatment group was treated with Heqi San on the basis of the control group. Both groups were treated for 3 months. The FPG was determined by glucose oxidase method, and fasting insulin (FINS), TC, TG, LDL-C, HDL-C level were measured by radio immunoassay, and the insulin resistance index (IR) was measured by the method of HOMA-IR. The luteotropic hormone (LH), pro follicle stimulating hormone (FSH) and testosterone (T) were detected by the automatic electrochemical light detector, and the ratio of LH/FSH was calculated. The ovarian volume and body mass index changes and clinical effect were evaluated. Results After treatment, the BMI (20.09 ± 3.12 kg/cm2 vs. 23.39 ± 1.43 kg/cm2, t=6.889), FPG (4.44 ± 0.17 mmol/L vs. 4.74 ± 0.16 mmol/L, t=6.945), FINS (10.69 ± 2.41 IU/L vs. 16.29 ± 5.95 IU/L, t=4.778), TC (3.91 ± 0.50 mmol/L vs. 4.20 ± 0.39 mmol/L, t=2.505), LDL-C (2.64 ± 0.63 mmol/L vs. 3.18 ± 0.62 mmol/L, t=3.346), LH (8.70 ± 2.44 U/L vs. 10.27 ± 2.69 U/L, t=2.934), the ratio of LH/FSH (1.33 ± 0.58 vs. 2.18 ± 0.56, t=5.775), T (1.73 ± 0.74 nmol/L vs. 2.95 ± 1.10 nmol/L, t=5.040) and ovarian volume (12.61 ± 2.29 mm3 vs. 14.26 ± 2.52 mm3, t=6.982) in the treatment group were significantly lower than those in the control group (P<0.01 or P<0.05). The FSH (7.33 ± 2.28 U/L vs. 5.95 ± 1.20 U/L, t=2.934) in the treatment group were significantly higher than those in the control group (P<0.05). The total effective rate in the treatment group was 83.3% (25/30) and 63.3% (19/30) in the control group. The difference between the 2 groups was statistically significant (χ2=3.068, P=0.050). Conclusions The Heqi San combined with metformin can effectively improve the body mass index, glucose metabolism, lipid metabolism index and sex hormone level, and reduce the volume of ovary in patients with PCOS, and the curative effect is better than that of oral metformin alone.
ABSTRACT
To summarize the clinical experience of Professor WANG Meng-yong in the treatment of uric acid nephropathy. Professor WANG believes that the disease is mainly caused by spleen and kidney deficiency, disorder of function of Sanjiao, and pathological products, such as phlegm dampness and blood stasis and other metabolic disorders. Therefore, the treatment should distinguish symptoms and essence. Starting from pathogenesis and pathological features of spleen and kidney deficiency and phlegm dampness and blood stasis, the treatment should flexibly apply the methods of nourishing spleen and kidney, reducing phlegm and dispelling humidity, and activating blood and using diuretic of hydragogue to alleviate water retention, which can greatly reduce side effects caused by the long-term use of Western medicine and the onset of gout, and then to help disease recovery.
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Objective To make a sensitive and specific method for quantitatively determination of hydrogen peroxide in water. Methods The strong oxide can oxidize potassium iodide to produce iodine in hydrochloric acid that reacts on amylum to produce iodine blue. In a range of concentration the colour of iodine blue accords with Bill's law. Firstly the gross of hydrogen peroxide and the other strong oxides in the sample were determined. Secondly, on the action of catalase the hydrogen peroxide was decompounded into oxygen and water, then, hydrogen peroxide lost its characteristic of oxidation, the other oxides without hydrogen peroxide in the sample were determined. The difference of the two determined results is the content of hydrogen peroxide. Results The calibration curve was linear between 0 to 2 ?g/ml (10 ?g/5 ml). The relative standard deviation was less than 1.2%. The rates of recovery were 98.7%-101.3%. The detection concentration was 0.08 mg/L(0.08 ?g/ml). Conclusion This method is simple, rapid, sensitive and hardly to be disturbed by any other strong oxidizers. This method is suitable for trace hydrogen peroxide analysis of source water and drinking water.
ABSTRACT
Objective To evaluate the safety of the levels of fluoride,arsenic and lead in toothpaste and the microbiological index of the toothpaste saled in Tianjin. Methods 60 tubes of toothpaste were sampled from the department stores and shops in Tianjin. The toothpaste samples included 14 tubes of commen toothpaste,18 tubes of medicated toothpaste,28 tubes of toothpaste blended with fluoride. Among 28 tubes of fluoride-adding toothpaste,6 tubes were specially used for children,19 tubes were domestic products for adults,3 tubes were imported for adults. All of the domestic toothpaste sampled were made in more than 10 cities and privinces such as: Tianjin,Beijing,Shanghai,Guangdong,etc. The levels of fluoride in toothpaste were determined by ion selective electrode,arsenic and lead were determined by inductively coupled plasma emission spectroscopy,the microbiological indexes were determined based on GB8372-1995 (toothpaste?雪. Results The contentes of soluble fluoride were 539-877 mg/kg for 5 tubes of fluoride-adding toothpaste used for children, 1 582-1 697 mg/kg for 3 tubes of domestic fluoride-adding toothpaste used for adults. The content of lead in an tubes of imported toothpaste was as high as 43.09 mg/kg,2.9 time the value of the national standard. The total count of bacteria,the count of fecal coliform,Paeruginosa,Staph aureus in 52 tubes of toothpaste sampled met the requirement of the related national standards. Conclusion The sanitary quality of 60 tubes of toothpaste sampled for this study saled in Tianjin was qualified in general,but very few had the sanitary problems in the aspects of fluoride excess in domestic fluoride-adding toothpaste and lead excess in imported toothpaste.